| 补体系统基因单核苷酸多态性及其与疾病的关系 |
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| 引用本文： | 王志富[综述],;贺福初,;周钢桥[审阅].补体系统基因单核苷酸多态性及其与疾病的关系[J].国外医学：分子生物学分册,2009(2):130-133. |
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| 作者姓名： | 王志富[综述] ;贺福初 ;周钢桥[审阅] |
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| 作者单位： | [1]蛋白质组学国家重点实验室北京蛋白质组研究中心军事医学科学院放射与辐射医学研究所,北京市100026; [2]中国医学科学院基础医学研究所北京协和医学院基础学院,北京市100730 |
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| 基金项目： | 通讯作者国家重点基础研究发展规划项目（973计划）（No.2005C-B522602）、国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”项目（No.2008ZX10002-016）,北京市科技新星人才基金（No.2006A54） |
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| 摘 要： | 天然免疫系统在病原微生物入侵的初始阶段发挥着重要的防御作用，其中补体系统可快速识别、杀伤和清除病原微生物，对疾病的发生、发展和转归起着重要的作用。文章综述了补体系统各成份单核苷酸多态性与疾病的关联研究进展，在DNA水平上揭示了补体系统遗传多态性对疾病发生、发展和转归的影响，对疾病的预防和个体化治疗具有重要的意义。
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| 关 键 词： | 单核苷酸多态性 补体 天然免疫 |
Association of Single Nucleotide Polymorphisms in Complement System with Diseases |
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| Institution: | WANG Zhifu, HE Fuchu, ZHOU Gangqiao(1The State Key Laboratory of Proteomics, Belting Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing , 102206, China 2Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100730, China) |
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| Abstract: | Innate immune system plays a crucial defensive role in the initial invading stage of pathogenic microorganisms. Complement system, one of the vital parts of innate immune system, can rapidly recognize, destroy and clean pathogenic microorganisms and plays an important role in occurrence, development and turnover of diseases. It has been reported that the single nucleotide polymorphisms of the complement system are associated with disease development. Understanding of genetic factors contributing to pathogenesis of diseases may facilitate early precaution, thus improving treatment of diseases. |
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| Keywords: | single nucleotide polymorphism complement innate immune |
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