| e6-ap与蛋白降解 |
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| 引用本文： | 周颖[综述] ;卫莹[综述] ;凌斌[审阅]. e6-ap与蛋白降解[J]. 国外医学:分子生物学分册, 2009, 0(5): 447-450 |
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| 作者姓名： | 周颖[综述] 卫莹[综述] 凌斌[审阅] |
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| 作者单位： | 安徽省分子医学重点实验室 安徽医科大学附属省立医院分子实验室,合肥市230001 |
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| 基金项目： | 安徽省自然科学基金（No.090413117） |
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| 摘 要： | e6-ap基因是HECTE3蛋白家族成员,根据N端的不同分为3个转录本,编码的3种蛋白均具有降解蛋白的功能。E6-AP的功能复杂,主要包括：①降解抑癌基因如p53、pml、tsc2、pdz家族基因的功能;②诱导htert基因启动子激活、提高端粒酶活性的功能;③与C型肝炎病毒的核心蛋白结合,参与r6基因的降解;④双向调节固醇类激素受体的表达;⑤调节ANNEXINA1蛋白的表达、促进其降解。E6-AP的蛋白表达受泛素及E6的调控,在肿瘤发病机制中起着重要作用。
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| 关 键 词： | E6-AP P53 泛素 |
E6-AP and Protein Degradation |
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| Affiliation: | ZHOU Ying, WEI Ying, LING Bin( Anhui Provincial Key Laboratory of Molecular Medicine, Molecular Laboratory of Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, 230001, China) |
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| Abstract: | E6-AP, one of HECT E3 protein family members, is divided into three different transcripts on the basis of its N-terminus that encodes three proteins with the ability of protein degradation. The function of E6-AP is complicated, including ： ① degrading tumor suppressor genes such as p53, PML, TSC2, PDZ family of genes ;② inducing activation of hTERT promoter and enhancing telomerase activity;③ binding to hepatitis C virus core protein, and participating in degradation of Rb gene; ④ dually regulating expression of steroid hormone receptor; ⑤ regulating expression of annexin A1 protein and promoting its degradation. E6-AP is regulated by ubiquitin and E6, and plays an important role in tumorigenesis. |
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| Keywords: | E6-AP p53 ubiquitin |
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