Treatment with 50000 IU Vitamin D2 Every Other Week and Effect on Serum 25-Hydroxyvitamin D2, 25-Hydroxyvitamin D3, and Total 25-Hydroxyvitamin D in Aclinical Setting |
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| Institution: | 1. Section of Endocrinology and Diabetes, Maine Medical Center, Portland, Maine;2. Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Boston Medical Center, Boston, Massachusetts;3. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.;1. From the Division of Otolaryngology-Head & Neck Surgery, University of Connecticut School of Medicine, Farmington, Connecticut;2. Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia;3. Department of Otolaryngology-Head & Neck Surgery, Boston University Medical Center, Boston, Massachusetts;4. Section of Endocrinology, Diabetes, and Nutrition, Boston University Medical Center, Boston, Massachusetts;5. Department of General Surgery, Boston University Medical Center, Boston, Massachusetts;6. Department of General Surgery, Stamford Hospital, Stamford, Connecticut.;1. Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115;2. Department of Biological Sciences, Kingsborough Community College, 2001 Oriental Boulevard, Brooklyn, NY 11235;1. Seoul National University Hospital, Seoul, Republic of Korea;2. University of Ulsan College of Medicine, Seoul, Republic of Korea;3. Department of Neurology, Konkuk University School of Medicine, Seoul, Republic of Korea;4. UCB Pharma, Monheim, Germany;5. UCB Pharma, Brussels, Belgium;6. UCB Pharma, Tokyo, Japan;7. Injie University Haeundae Paik Hospital, Busan, Republic of Korea |
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| Abstract: | ObjectiveTo examine the effect of 50 000 IU-vitamin D2 supplementation in a clinical setting on serum total 25-hydroxyvitamin D (25OH]D), 25-hydroxyvitamin D2 (25OH]D2), and 25-hydroxyvitamin D3 (25OH]D3).MethodsThis retrospective cohort study was performed in an urban tertiary referral hospital in Boston, Massachusetts. Patients who had been prescribed 50 000 IU vitamin D2 repletion and maintenance programs were identified through a search of our electronic medical record. Baseline and follow-up total serum 25(OH)D, 25(OH)D2, and 25(OH)D3 levels were compared.ResultsWe examined the medical records of 48 patients who had been prescribed 50 000 IU vitamin D2 in our clinic. Mean ± standard deviation baseline total 25(OH) D was 31.0 ± 10.6 ng/mL and rose to 48.3 ± 13.4 ng/mL after treatment (P <.001). 25(OH)D2 increased from 4.2 ± 4.3 ng/mL to 34.6 ± 12.3 ng/mL after treatment (P <.001), for an average of 158 days (range, 35-735 days). Serum 25(OH)D3 decreased from 26.8 ± 10.8 ng/mL to 13.7 ± 7.9 ng/mL (P <.001).ConclusionsFifty thousand IU vitamin D2 repletion and maintenance therapy substantially increases total 25(OH)D and 25(OH)D2 despite a decrease in serum 25(OH)D3. This treatment program is an appropriate and effective strategy to treat and prevent vitamin D deficiency.(Endocr Pract. 2012;18:399-402) |
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