Gender,Brain-Derived Neurotrophic Factor Val66Met,and Frequency of Methamphetamine Use |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA, USA;2. Translational Addiction Research Center, Washington State University, Pullman, WA, USA;3. Department of Diving Medicine, Second Military Medical University, Shanghai, China;4. Faculty of Pharmacy, University of Manitoba, Winnipeg, MB, Canada;5. Department of Physiology and Pharmacology, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA, USA;1. Inserm U-1173, Laboratory of Pharmacology-Toxicology, Versailles Saint-Quentin-en-Yvelines University, AP–HP, Raymond-Poincaré University Hospital, 104, boulevard Raymond-Poincaré, 92380 Garches, France;2. Emergency department, Sud-Ardennes Hospital, 08300 Rethel, France;3. Paris Poison Control Centre, AP–HP Saint-Louis-Lariboisière-Fernand-Widal University Hospital, 75475 Paris, France;4. Paris Diderot University, Sorbonne Paris Cité, 75010 Paris, France;1. Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan;2. United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Yanagido, Gifu 501-1193, Japan |
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| Abstract: | BackgroundFrequency of pretreatment methamphetamine (MA) use is an important predictor of outcomes of treatment for MA dependence. Preclinical studies suggest females self-administer more MA than males, but few clinical studies have examined potential sex differences in the frequency of MA use. Estrogen increases expression of brain-derived neurotrophic factor (BDNF), which has effects on MA-induced striatal dopamine release and protects against MA-induced neurotoxicity.ObjectiveWe examined potential effects of sex, the Val66Met polymorphism in BDNF, and their interaction on frequency of MA use among 60 Caucasian MA-dependent volunteers screening for a clinical trial.MethodsData was taken from 60 Caucasian MA-dependent volunteers screening for a clinical trial.ResultsFemales reported significantly more pretreatment days with MA use in the past 30 days than males. There was a significant interaction between sex and BDNF Val66Met, with the highest frequency of MA use among females with Val/Val genotype.ConclusionsThese results, although preliminary, add to the literature documenting sexual dimorphism in response to stimulants, including MA, and suggest a potential biological mechanism involving BDNF that might contribute to these differences. Additional research characterizing the biological basis of altered response to MA among females is warranted. |
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