The tetranuclear copper active site of nitrous oxide reductase: the CuZ center |
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Authors: | Simone Dell’Acqua Sofia R Pauleta Isabel Moura José J G Moura |
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Institution: | 1.REQUIMTE/CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia,Universidade Nova de Lisboa,Caparica,Portugal |
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Abstract: | This review focuses on the novel CuZ center of nitrous oxide reductase, an important enzyme owing to the environmental significance
of the reaction it catalyzes, reduction of nitrous oxide, and the unusual nature of its catalytic center, named CuZ. The structure
of the CuZ center, the unique tetranuclear copper center found in this enzyme, opened a novel area of research in metallobiochemistry.
In the last decade, there has been progress in defining the structure of the CuZ center, characterizing the mechanism of nitrous
oxide reduction, and identifying intermediates of this reaction. In addition, the determination of the structure of the CuZ
center allowed a structural interpretation of the spectroscopic data, which was supported by theoretical calculations. The
current knowledge of the structure, function, and spectroscopic characterization of the CuZ center is described here. We would
like to stress that although many questions have been answered, the CuZ center remains a scientific challenge, with many hypotheses
still being formed. |
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