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In vitro screening of seaweed extract on the proliferation of mouse spleen and thymus cell |
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| Authors: | Youngwan Seo Sung-Ho Kang Hee-Jung Lee You Ah Kim Hyun Joo Youn Burm-Jong Lee Hosung Chung |
| Affiliation: | 1. Division of Marine Environment and Bioscience, Korea Maritime University, 606-791, Busan, Korea 2. Korea Polar Research Institute, KORDI, 426-744, Ansan, Korea 3. Research Institute of Marine Science and Technology (RIMST), Korea Maritime University, 606-791, Busan, Korea 4. Department of Microbiology and School of Biotechnology & Biomedical Science, Inje University, 621-749, Gimhae, Korea 5. Department of Chemistry & Biohealth Products Research Center, Inje University, 621-749, Gimhae, Korea |
| Abstract: | A total number of 31 types of seaweed were assessed with regard to their effects on the proliferation of mouse spleen and thymus cells in a culture, using an MTT reduction assay. Acetone:dichloromethane (1∶1) extracts of three seaweed plants:Derbesia marina, Sargassum sp., andHisikia fuziformis, exhibited significantly positive effects on the survival of mouse spleen and thymus cellsin vitro. The acetone: dichloromethane (1∶1) extracts ofSargassum sp., in particular, much more potent effects on thymus cell activation than did any of the other types of seaweed. However, the methanol extracts ofSargassum ringgoldianium andChondrus crispus exerted a stimulatory influence only on the proliferation of mouse spleen cells, whereas the methanol extracts ofGrateloupia lanceolata exhibited significant cell proliferation properties in both spleen and thymus cells. |
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