Adhesive binding of rokitamycin to Staphylococcus aureus ribosomes |
| |
| Authors: | Ikutarou Endou Mayumi Matsuoka Yoshinori Nakajima |
| |
| Affiliation: | Division of Microbiology, Hokkaido Institute of Pharmaceutical Sciences, Japan. |
| |
| Abstract: | Rokitamycin (RKM), a 3"-O-propionyl derivative of leucomycin A5, is bactericidal against staphylococci near the minimum inhibitory concentrations. RKM bound to ribosomes before-hand is only slightly displaced by erythromycin or josamycin, or even by RKM itself. The adhesive binding of the RKM-ribosome complex might prove to be the lethal event for susceptible staphylococci. |
| |
| Keywords: | Macrolide antibiotic Bactericidal effect Irreversible binding TMS-19-Q |
|
