Estrogens prevent calcium-induced release of cytochrome c from heart mitochondria |
| |
Authors: | Morkuniene Ramune Jekabsone Aiste Borutaite Vilmante |
| |
Institution: | Institute for Biomedical Research, Kaunas University of Medicine, LT-3007 Kaunas, Lithuania. |
| |
Abstract: | We investigated the effect of estrogens on heart mitochondrial functions and whether estrogens can prevent calcium-induced release of cytochrome c from mitochondria. 10 nM-10 microM 17beta-estradiol or 4-hydroxytamoxifen did not affect mitochondrial respiration rate and membrane potential in state 3 and state 4. Higher concentrations of both agents decreased state 3 respiration rate and membrane potential. 100 nM 17beta-estradiol and 4-hydroxytamoxifen blocked high calcium-induced cytochrome c release from mitochondria but not mitochondrial swelling. Thus, at physiological concentrations estrogens do not affect mitochondrial respiratory functions but protect heart mitochondria from high calcium-induced release of cytochrome c. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|