|
|||||
|
|
Determination of nifedipine in human plasma by flow-injection tandem mass spectrometry |
|
| Authors: | Jan Dankers Jos van den Elshout Gertrude Ahr Erich Brendel Cees van der Heiden |
| Institution: | a BCO Analytical Services, PO Box 2176, 4800 CD Breda, The Netherlands b Bayer, Institute of Clinical Pharmacology, Pharma Research Centre, B. 405, D-42096 Wuppertal, Germany |
| Abstract: | For use in clinical studies, a fast and sensitive assay method was developed for the determination of nifedipine in human plasma samples. The assay method is based on tandem mass spectrometry detection (HPLC–MS–MS). The effect of flow injection as well as HPLC separation on the results of the nifedipine determination were evaluated. The limit of quantification is 0.5 ng/ml and the accuracy (as determined by spiking recovery) was found to be good. |
| Keywords: | Nifedipine |
| 本文献已被 ScienceDirect 等数据库收录！ | |