Secretin modulation of behavioral and physiological functions in the rat |
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| Authors: | C G Charlton R L Miller J N Crawley G E Handelmann T L O'Donohue |
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| Institution: | 1. Neuroendocrinology Unit, Experimental Therapeutics Branch National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health, Bethesda, MD 20205 USA;2. Division of Clinical Pharmacology, Howard University, Washington, DC 20059 USA;3. Unit of Behavioral Neuropharmacology, Clinical Neuroscience Branch National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20205 USA;4. Laboratory of Clinical Science, National Institute of Mental Health National Institutes of Health, Bethesda, MD 20205 USA |
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| Abstract: | The effect of secretin on behavioral and physiological functions in the rat was investigated. Secretin injected intracerebroventricularly (ICV) significantly increased defecation and decreased novel-object approaches in rats. The peptide showed no significant effects on stereotypic behavior (gnawing, grooming and rearing), open-field locomotor activity however was significantly decreased, an effect that was probably due to a decreased propensity for the rats to initiate locomotor responses. In addition, secretin showed significant effects on respiration rate in anesthetized rats. When the peptide was injected in the lateral ventricle a decrease in respiration rate occurred, but when the brain was perfused from the lateral ventricle to the cisterna magna increases in respiration rate occurred. These data, combined with the facts that secretin and secretin receptors have been identified in the brain indicate that secretin may play a neurotransmitter or neuroregulator role in the central nervous system. |
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| Keywords: | Secretin Novel-object approaches Open field locomotor activity Respiratory Defecation |
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