Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium |
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Authors: | Kyung-Chul?Choi Nelly?Auersperg Email author" target="_blank">Peter?CK?LeungEmail author |
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Institution: | (1) Department of Obstetrics and Gynaecology, BC Children's and Women's Hospital, University of British Columbia, V6H 3V5 Vancouver, British Columbia, Canada |
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Abstract: | Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse
array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. It has been demonstrated
that MAPKs are activated by external stimuli including chemotherapeutic agents, growth factors and reproductive hormones in
ovarian surface epithelial cells. Thus, the MAPK signaling pathway may play an important role in the regulation of proliferation,
survival and apoptosis in response to these external stimuli in ovarian cancer. In this article, an activation of the MAPK
signaling cascade by several key reproductive hormones and growth factors in epithelial ovarian cancer is reviewed. |
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Keywords: | |
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