The selection of virus-resistant Chinese hamster ovary cells. |
| |
| Authors: | R Taber V Alexander N Wald |
| |
| Affiliation: | Department of Medical Viral Oncology Roswell Park Memorial Institute and Graduate Faculty in Microbiology State University of New York at Buffalo (Roswell Park Division) Buffalo, New York 14263 USA |
| |
| Abstract: | We have selected Chinese hamster ovary (CHO) cells resistant to infection by encephalomycarditis (EMC) virus. Thus far, we have obtained five lines resistant to EMC, all of which manifest different phenotypes. Three of the five are not persistently infected with virus, while two lines produce infectious virus and grow in its presence. The nonpersistently infected lines exhibit different resistance profiles to the other viruses we have tested, and they are stable in nonselective growth conditions. Their resistance appears to be due to a genetic alteration in the cell. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
