Methyl iodide, a potent inducer of the adaptive response without appreciable mutagenicity in E. coli |
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| Authors: | K Takahashi Y Kawazoe |
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| Affiliation: | 1. Laboratory of Marine Environmental Science, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan;2. Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China;3. Institute of Nature and Environmental Technology, Kanazawa University, Kanazawa 920-1192, Japan;1. Gilead Sciences, 333 Lakeside Drive, Foster City, CA, USA;2. MRL, Merck & Co., Inc., W 45-316, West Point, PA, USA;3. AstraZeneca, Drug Safety and Metabolism, Innovative Medicines and Early Development, United Kingdom;4. AstraZeneca, Silk Road Business Park, Macclesfield, Cheshire, SK10 2NX, United Kingdom;5. Pfizer Worldwide Research and Development, Genetic Toxicology, Eastern Point Road, Groton, CT, USA;6. AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL, USA;7. Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str., 88397 Biberach, Germany;8. Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA;9. GlaxoSmithKline R&D, Park Road, Ware, Hertfordshire, SG12 0DP, United Kingdom;10. Novartis AG, NIBR, Klybeckstrasse, CH-4057 Basel, Switzerland;11. Bristol-Myers Squibb, 1 Squibb Dr, New Brunswick, NJ, USA;12. Eli Lilly and Company, Indianapolis, IN, USA;13. Sanofi, Vitry-sur-Seine, France;1. Laboratório de Ecotoxicologia e Microbiologia Ambiental, Faculdade de Tecnologia, Universidade Estadual de Campinas (FT/UNICAMP), Limeira, SP, Brazil;2. Laboratório de Farmacogenética e Biologia Molecular, Faculdade de Ciências Médicas, Universidade José do Rosário Vellano (UNIFENAS), Alfenas, MG, Brazil;3. Centro de Pesquisa e Pós-graduação em Ciência Animal, Área de Patologia e Farmacologia Animal, Universidade José do Rosário Vellano (UNIFENAS), Alfenas, MG, Brazil;4. Laboratório de Microbiologia e Imunologia & Laboratório de Genética Molecular, Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas (FOP/UNICAMP), Piracicaba, SP, Brazil;1. Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Rd. Zuchongzhi, Zhangjiang Hi-Tech Park, Shanghai, 201203, China;2. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China |
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| Abstract: | ![]()
Methyl iodide (MeI), a very weak mutagen, induced the adaptive response in E. coli to a similar extent to those induced by potently mutagenic methylating agents. MeI potentiated the mutagenicity of a methylating mutagen, N-methyl-N-nitrosourea, by its co-treatment. These results might give indication that MeI directly methylates O6-methylguanine-DNA methyltransferase resulting in induction of the adaptive response and depletion of the repair capacity of enzyme. |
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