Thyroid function and trisomy 21. TSH increase and rT3 deficiency |
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| Authors: | J Lejeune M Peeters M C de Blois M Bergère A Grillot M O Rethoré G Vallée M Izembart J P Devaux |
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| Institution: | Institut de Progenèse, Centre Claude Bernard sur les Maladies de l'Intelligence, Paris. |
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| Abstract: | An excess of thyrotropin (TSH) with normal levels of tetraiodothyronine (T4) and of 3,5,3'-triiodothyronine (T3) was confirmed in the serum of 78 trisomy 21 children. A severe deficiency of 3,3',5'-triiodo-thyronine (rT3 or reverse T3) was observed and the decrease of the rT3/TSH ratio was highly significant. These new facts suggest that the rT3 deficiency plays a peculiar role in trisomy 21 (maybe through the regulation of one or few steps of monocarbons' metabolism). A systematic control of thyroid function (including the patient's rT3 level) is mandatory for the follow-up of every trisomy 21 patient. |
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