炎症小体在动脉粥样硬化发生发展中的研究进展

炎症小体(inflammasome)是免疫细胞内由多种蛋白质所组成的复合体,属于胞浆型模式识别受体(pattern recognition receptor,PRR)。它作为固有免疫系统的重要组分在机体免疫反应和疾病发生过程中具有重要作用。近年来的研究表明炎症小体是炎症免疫反应的核心。由于能被多种类型的病原体或危险信号所激活,NLRP3(NOD样受体蛋白-3)炎症小体在多种疾病过程中,包括动脉粥样硬化症、家族性周期性自身炎症反应、阿尔海默茨病和2型糖尿病等都发挥了关键作用。因此,NLRP3(NOD样受体蛋白-3)炎症小体可能为各种炎症性疾病,包括动脉粥样硬化的治疗提供新的靶点。本文将对炎症小体在动脉粥样硬化发生发展中发挥的作用进行综述。

Role of Inflammasome in the Development of Atherosclerosis

Inflammasome is composite body which composed of a variety of proteins in the immune cells, and it belongs to the cytoplasm type pattern recognition receptors (PRRs). As an important part of innate immune system, it plays a vital role in the process of the body''s immune response and disease process. Recent studies show that inflammsome is the core of inflammatory immune response. As it can be triggered by a variety of types of pathogens or dangerous signals, NLRP3 Inflammasome plays a key role in a vast amount of diseases, including Atherosclerosis, Familial periodic inflammatory response itself, Alzheimer''s disease, Type 2 diabetes mellitus and so on. Therefore, NLRP3 Inflammasome may provide new therapeutic targets for a multitude of inflammatory diseases, including Atherosclerosis. This article will focus on the role inflammasome plays in the development of Atherosclerosis.