重组人脑利钠肽的临床应用进展

近年来,随着心力衰竭、肺动脉高压的病理生理及分子机制的深入研究,使上述疾病在临床药物治疗方面有了很大的进步,其中人脑利钠肽(BNP)作为体内唯一天然的肾素-血管紧张素-醛固酮拮抗剂在诊断及治疗心力衰竭等方面均引起了广泛关注,但由于其在心衰状态下降解快且生物活性明显减弱而限制了临床应用。因此,在心力衰竭治疗上补充外源性BNP成为了又一研究热点。重组人脑利钠肽(rhBNP)是一种人工合成的内源性激素,具有扩张血管、排钠利尿、降低心脏前后负荷、抑制肾素-血管紧张素-醛固酮系统和交感神经系统等作用,能够有效的改善充血性心力衰竭患者的血流动力学障碍。新近研究表明,rhBNP在治疗心血管疾病方面疗效显著,本文将就其在临床中的应用予以综述。

Advances in Clinical Application of Recombinant Human Brain Natriuretic Peptide

ABSTRACT:In recent years, with the further research of pathological physiological and molecular mechanism about heart failure and pulmonary hypertension, the pharmacotherapy on these diseases have a great advance. The human brain natriuretic peptide (BNP), as the only natural renin-angiotensin-aldosterone antagonist in the diagnosis and treatment of heart failure, caused wide public concern. Therefore, exogenous BNP become one hot research spot in heart failure treatment. Recombinant human brain natriuretic peptide (rhBNP) is a kind of synthetic endogenous hormone. It has the functions of vasodilation, diuresis, reducing the preload and afterload of cardiac, inhibiting the renin-angiotensin-aldosterone system and sympathetic nervous system, and can effectively improve the hemodynamic of congestive heart failure patients.Recent research shows that rhBNP have remarkable effection in the treatment of cardiovascular diseases, so this article is aimed to review the clinical application of rhBNP.