壳聚糖膜在治疗宫颈疾病中的降解时间与影响因素的研究

目的:研究不同壳聚糖膜在体外及体内的生物降解时间。方法:用不同分子量壳聚糖为制膜材料,将4组不同组成成分的壳聚糖溶于1.5%乙酸中,配成1%溶液,加入辅料烘干成膜称其重量,剪成大小相等的小块,精称后放置于弱酸介质和雌鼠阴道中。定时取样,水洗,烘干后称重,按W-W'W×100%算得降解百分率。结果:1号较2号降解时间快,而加入PVA的3号与4号又较1号与2号更快。结论:壳聚糖是一种生物可降解材料,壳聚糖膜的降解时间与其分子量、PVA比例、介质酸性强度等因素相关。

Study on Degradation Time and Influencing Factors of Chitosan Membrane in the Treatment of Cervical Diseases

Objective:To explore the vitro and vivo degradation time of chitosan films.Methods:Using chitosan with different molecular weight as the membrane material, four groups of different compositions of chitosan dissolved in 1.5%acetic acid, Formulated as a 1%solution, after drying and weighing adding accessories, Cut into pieces of equal size, weighed and placed in a weak acid medium and Female rats vagina. Regular sampling, washed, dried and weighed. Calculated the percentage degradation by (W-W'')/W× 100 %.Results:No.1 is faster than No.2, PVA added in the No.3 and No.4 is faster than No.1 and No.2.Conclusion:chitosan is a kind of biodegradable material, the degradation of chitosan membrane is related to its molecular weight, PVA ratio and the acidic strength of the mediumetc.