HuR和PDGFC在乳腺癌组织中的表达及相关性分析

目的:探讨HuR和PDGFC在乳腺癌组织中的表达及相关性。方法:选取2008年至2009年80例手术切除并有完整的临床与病理资料的乳腺癌患者为研究对象,采用免疫组化法对乳腺癌组织中HuR和PDGFC的表达进行检测,并进行统计学分析。分析两者的表达与乳腺癌pTNM分期的关系,以及两者之间的相关性。结果:乳腺癌组织中HuR和PDGFC的表达均与pTNM分期有相关性(均P0.05),且两者的表达呈正相关(r=0.608,P0.05),具有统计学意义。结论:乳腺癌中HuR和PDGFC的高表达可能参与了乳腺癌的发生发展过程,有望影响乳腺癌的术后治疗。两者的表达产物呈正相关,HuR的表达产物可能通过对PDGFC的表达进行调控促进乳腺癌的发生与发展。

Expressions of HuR and PDGFC in Breast Cancer and its Correlation Analysis

Objective:To investigate the expressions of HuR and PDGFC in breast cancer and its correlation.Methods:From2008 to 2009, 80 cases of surgical operation and clinical and pathological data of breast cancer patients as the research object.The expressions of HuR and PDGFC in breast cancer tissue samples were detected by immunohistochemical techniques and analyzed statistically. The correlation between expressions of both genes and pTNM stages were analysed as well as correlation between them.Results:Both of their expressions were correlated with pTNMstages(P<0.05), and there was positive correlation between expression of HuR and PDGFC (r=0.608, P>0.05), which is statistically significant.Conclusion:The high expressions of HuR and PDGFC possibly participated the procession of the tumogenesis growth and prognosis of breast cancer which may play a very important role in the therapy after operation. Their expressions are positively correlated, the products of HuR expression may play an important role on the in set and progression of breast cancer by regulating the expression of PDGFC.