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The calcium/NFAT pathway: role in development and function of regulatory T cells

Institution:	1. Departamento de Bioquímica e Imunologia, Instituto de Ciência Biológicas, Univtreersidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil;2. Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Presyes 748, 05508-000 São Paulo, SP, Brazil;3. Instituto Nanocell, Rua Santo Antônio, 420, 35500-041 Divinópolis, MG, Brazil;4. Universidade Federal do ABC, Centro de Matemática, Computação e Cognição, Rua Arcturus (Jd Antares), 09606-070, São Bernardo do Campo, SP, Brazil

Abstract:	Calcium signals are essential for diverse cellular functions in the immune system. Sustained Ca²⁺ entry is necessary for complete and long-lasting activation of calcineurin/NFAT pathways. A growing number of studies have emphasized that Ca²⁺/calcineurin/NFAT pathway is crucial for both development and function of regulatory T cells.

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