Human Th17 cells in infection and autoimmunity |
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| Institution: | 1. Internal Medicine B and Clinical Immunology, Kaplan Medical Center, Rehovot, Israel;2. Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel;3. Department of Rheumatology, Tel Aviv Medical Center, Tel-Aviv, Israel;4. Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;5. Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, MD, USA;1. Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China;2. Key Laboratory of Zoonoses Research, Ministry of Education, The First Hospital of Jilin University, Changchun 130021, China;3. Department of Nephrology, The First Hospital of Jilin University, Changchun 130021, China;4. University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA;5. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China |
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| Abstract: | IL-17-producing T cells (Th17) have been identified in mice as a distinct lineage of CD4+ T helper cells. Since their discovery, efforts have been made in characterizing human Th17 cells and the factors involved in their differentiation and in understanding the role these cells play in protective immunity and autoimmune diseases. |
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