The stability and properties of bimolecular lipid leaflets in aqueous solutions |
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| Affiliation: | 1. Institute for Integrative Biology of the Cell, UMR9198, CNRS, Université Paris-Sud, CEA, Gif-sur-Yvette, France;2. Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Hokkaido Center, Sapporo, Japan;3. Graduate School of Agriculture, Hokkaido University, Sapporo, Japan;4. National Institute for Basic Biology (NIBB), Okazaki, Japan;5. Department of Biology, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany;1. Saratov State University, 83 Astrakhanskaya, Saratov 410012, Russia;2. Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachya 112, Saratov 410012, Russia;1. Faculty of Pharmacy, University of Coimbra, Portugal;2. CNC – Center for Neuroscience and Cell Biology, University of Coimbra, Portugal;3. Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Portugal;4. Centro de Investigação em Química, Department of Chemistry and Biochemistry, Faculty of Science, University of Porto, Rua do campo Alegre s/n, P 4169-007 Porto, Portugal;5. UCIBIO/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Science, University of Porto, 4169-007 Porto, Portugal;1. Department of Bio and Brain Engineering, KAIST, Daejeon 34141, Republic of Korea;2. KAIST Institute for Health Science and Technology, Daejeon, Republic of Korea |
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| Abstract: | This paper is intended to be a mainly theoretical examination of the physical properties and the stability under various conditions of continuous lipoidal bimolecular leaflets in aqueous solutions. It is not accepted that such lipid structures are the effective permeability barriers in living cells but rather that the evidence for this structure is sufficiently strong to warrant a closer investigation of its physical and chemical behaviour. One of the main objects has been to examine the probable effect of well-known lytic substances on the stability of the bimolecular leaflet of lipid, and where possible to make some predictions which can be tested experimentally. Thus by comparing the lysis data for a number of cells with the predicted behaviour of the bimolecular leaflet it should ultimately be possible to produce substantial evidence as to the longrange structure of cell membranes.We have first considered qualitatively the energetics of bimolecular lipid leaflet formation and stability in terms of the nature of the lipid molecules, ionization, etc. Some brief remarks are offered on the rheological properties of the leaflets and their relation to mechanical strength in cell walls. The adsorption and effect on their stability of non-polar, non-ionic surface active, ionic surface active and protein molecules has been discussed. It has been suggested that some often proposed mechanisms of protein-lipid interaction are energetically unfavourable and must be discarded. Finally the value of monolayer penetration studies at the air/water interface as a guide to phenomena in bimolecular lipid leaflets has been considered. |
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