Tumor Suppressor Candidate 1 Suppresses Cell Growth and Predicts Better Survival in Glioblastoma |
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| Authors: | Rui Zhang Wan Yu Guanyu Liang Zhanjun Jia Zhengxin Chen Lin Zhao Yongsheng Yuan Xiaobin Zhou Daqian Li Shuying Shen Ning Liu Aihua Zhang Huibo Wang Gang Wang |
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| Institution: | 1.Department of Neurosurgery, Nanjing Children’s Hospital,Affiliated to Nanjing Medical University,Nanjing,China;2.Department of Neurosurgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,China;3.Hospital of Integrated Traditional Chinese and Western Medicine in Jiangsu Province,Nanjing,China;4.The Institute of Pediatrics,Affiliated to Nanjing Medical University,Nanjing,China;5.Department of Neurology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,China;6.Department of Microbiology & Immunology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,China;7.Department of Laboratory Medicine, The First Affiliated Hospital,Nanjing Medical University,Nanjing,China;8.The Institute of Biochemistry,Zhejiang University,Hangzhou,China;9.Chinese Glioma Cooperative Group (CGCG),Beijing,China |
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| Abstract: | Glioblastoma (GBM) is the most common malignant brain tumor with poor prognosis and limited treatment options. Tumor suppressor candidate 1 (TUSC1) was recently identified as a potential tumor suppressor in human cancers. However, the expression and potential function of TUSC1 in GBM remain unclear. Herein, we report that TUSC1 is significantly decreased in GBM tissues and cell lines. Patients with high levels of TUSC1 displayed a significant better survival compared with those with low levels of TUSC1. Functional experiments demonstrated that exogenous expression of TUSC1 inhibited GBM cell proliferation and induced G1 phase arrest by down-regulating CDK4. Moreover, overexpression of TUSC1 retarded tumor growth in vivo. Together, our findings revealed that TUSC1 might be a crucial tumor suppressor gene and a novel therapeutic target for GBM. |
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