非编码RNA调控血管平滑肌细胞成骨样表型转化的研究进展

分化成熟的血管平滑肌主要功能是收缩血管、调节血管周径及血压等.在高磷、高糖、维生素D3、炎症等因素的作用下,平滑肌细胞可转分化为成骨样细胞参与血管钙化的形成,诱发心脑血管不良事件.非编码RNA是经基因转录但不翻译为蛋白质的一类RNA总称,其通过调控多种细胞活动来参与机体的生理和病理过程.已有研究表明,非编码RNA可通过调控血管平滑肌细胞成骨样表型转化影响血管钙化的发生、发展.本文从微小RNA、长链非编码RNA、环状RNA几方面综述非编码RNA在血管平滑肌成骨样表型转化中的调节作用,有助于进一步了解血管钙化的分子机制以及发现防治血管钙化的新靶点.

Research Progress of Non-coding RNA Regulates Osteoblast-like Phenotype Transformation of Vascular Smooth Muscle Cells

The main functions of terminally differentiated vascular smooth muscle cells are contracting vessel, regulating vessel diameter and blood pressure, etc. Under the action of hyperphosphatemia, hyperglycemia, vitamin D₃, inflammation and other factors, vascular smooth muscle cells are transformed into osteoblast-like cells to participate in vascular calcification, which induce cardiovascular and cerebrovascular adverse events. Non-coding RNA is a general term for a variety of RNA types that transcribed from the human genome but lacking the ability to encode proteins. Non-coding RNA participates in the body''s physiological and pathological processes by regulating various cell activities. Studies have shown that non-coding RNA can affect the occurrence and development of vascular calcification by regulating the osteoblast-like phenotype transformation of vascular smooth muscle cells. This article reviews the regulatory role of non-coding RNA in osteoblast-like phenotypic transformation of vascular smooth muscle and vascular calcification from the aspects of microRNA, long non-coding RNA and circular RNA, which is helpful to further understand the molecular mechanism of vascular calcification and find new targets for the prevention and treatment of vascular calcification.