Subviral Dense Bodies of Human Cytomegalovirus Stimulate Maturation and Activation of Monocyte-Derived Immature Dendritic Cells |
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| Authors: | Caroline Sauer Sebastian Klobuch Wolfgang Herr Simone Thomas Bodo Plachter |
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| Affiliation: | Institute for Virologya;Department of Medicine III,b University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany |
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| Abstract: | Dendritic cells play a central role in the immune control of human cytomegalovirus (HCMV) infection. This work aimed at investigating the impact of noninfectious, subviral dense bodies of HCMV on the maturation and activation of dendritic cells (DC). Treatment of immature DC with dense bodies led to the maturation of these cells and significantly increased their capacity for cytokine release and antigen presentation. Dense body-activated DC may thereby contribute to the development of antiviral immunity. |
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