Trace elements in coronary heart disease |
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Authors: | M Krachler M Lindschinger B Eber N Watzinger S Wallner |
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Institution: | 1. Institute for Analytical Chemistry, Karl-Franzens-University Graz, Universit?tsplatz 1, A-8010, Graz, Austria 2. Department of Medicine, Karl-Franzens-University Graz, Auenbruggerplatz 15, A-8036, Graz, Austria
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Abstract: | Concentrations of 14 trace elements (Bi, Cd, Co, Cs, Cu, Hg, Mn, Pb, Rb, Sb, Sn, Sr, Tl, and Zn) were determined by inductively
coupled plasma mass spectrometry (ICP-MS) in 120 whole-blood and 121 plasma samples of 56 patients with angiographically documented
coronary heart disease (CHD). One serum and two wholeblood reference materials were analyzed for quality control. At baseline,
patients had elevated Co plasma as well as diminished Cu blood concentrations compared to healthy adults. The Zn concentrations
in whole blood were below or at the lower end of the normal range, but the concentrations in plasma were elevated. All other
trace elements were within the normal concentration ranges for healthy adults. After initial investigations, patients were
randomly assigned to an experimental group (N = 27) and to a usual care group (N = 29). Experimental group patients were prescribed a lifestyle program that included a low-fat diet and a weekly moderate
exercise. Patients were examined at baseline, after 6 and 12 mo for clinical assessment and fasting venous blood samples.
No significant time-course changes in concentrations of trace elements in blood and plasma during the clinical treatment in
both groups of patients could be observed. The experimental group patients lost weight and had lower blood pressure after
12 mo compared to baseline. The interventional therapy reduced the need for further revascularization procedures. |
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Keywords: | Trace elements coronary heart disease blood plasma low-fat diet activity program inductively coupled plasma mass spectrometry |
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