Expression of streptococcal plasmid-determined resistance to erythromycin and lincomycin in Escherichia coli |
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| Authors: | Horst Malke and Stig E Holm |
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| Institution: | (1) Department of Clinical Bacteriology, University of Umeå, S-90185 Umeå, Sweden;(2) Zentralinstitut für Mikrobiologic und experimentelle Therapie, DDR-69 Jena, German Democratic Republic |
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| Abstract: | Summary By using recombinant DNA techniques, we have constructed a chimeric plasmid, pSM7322 (10.8 kb), between the streptococcal erythromycin resistance vector plasmid pSM7 (6.4 kb) and the E. coli vector pBR322 (4.4 kb). As judged by the minimum inhibitory concentrations of erythromycin and lincomycin, pSM7-determined resistance to these antibiotics is expressed in E. coli. |
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