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Developmental studies on Drosophila melanogaster glutathione s-transferase and its induction by oxadiazolone |
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| Authors: | Abdelrahim A. Hunaiti Ahmed M. Elbetieha Motassim A. Obeidat Wajih M. Owais |
| Affiliation: | * Dean of Scientific Research and Higher Studies, Mu'tah University, Jordan † Department of Biological Sciences, Faculty of Science, Jordan University of Science and Technology, Jordan ‡ Department of Biological Sciences, Yarmouk University, Irbid, Jordan |
| Abstract: | Glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene was detected in various developmental stages of Drosophila melanogaster. The specific activity of the enzyme was 110, 35, 25 and 15 nmol/min/mg protein in crude extracts prepared from eggs, larvae, pupae and adult stages respectively. The enzymes from larval, pupal and adult stages were purified and compared. Incorporation of the widely used herbicide oxadiazolone at concentrations of 375 and 563 part/million into the culture media caused 4- and 2.5-fold increase in the enzyme activity in pupal and adult stages respectively. |
| Keywords: | Glutathione S-transferase Oxadiazolone Developmental Drosophila |
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