Evaluation of the antimutagenic potential of chitosan oligosaccharide: Rec, Ames and Umu tests |
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Authors: | Kyung-Soo Nam Yong-Ri Choi Yun-Hee Shon |
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Institution: | (1) Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University, Kyongju, 780-714, Korea;(2) Department of Chemistry, Pukyong National University, Pusan, 608-737, Korea |
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Abstract: | Two types of chitosan oligosaccharides (COS), COS I (1-kDa < MW < 3-kDa) and COS II (3-kDa < MW < 5-kDa), were tested for antimutagenic activities against chemical mutagens using Umu gene expression, Ames, and Bacillus subtilis Rec mutagenicity tests. At the highest chitosan oligosaccharide dose (1 mg) tested, mutagenic activity of indirect-acting mutagen was inhibited by 50% in the Umu gene expression system and in the Ames test. Chitosan oligosaccharide (0.01, 0.1 and 1 mg) also suppressed 4-nitroquinoline-N-oxide (NQO)-induced mutagenicity in the B. subtilis Rec– assay. |
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Keywords: | Ames test antimutagenicity chitosan oligosaccharide Rec assay Umu test |
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