Indices of oxidative stress in pregnancy with fetal growth restriction |
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| Authors: | Agata Karowicz-Bilinska Kornelia Kędziora-Kornatowska Grzegorz Bartosz |
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| Institution: | 1. High-Risk Pregnancy Unit, Medical University of ?ód?, Lodz, Polandagakar@interia.pl;3. Department and Clinic of Geriatry, Medical College in Bydgoszcz, Mikolaj Kopernik University of Torun, Bydgoszcz, Poland;4. Department of Molecular Biophysics, University of Lodz, Lodz, Poland;5. Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszow, Poland |
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| Abstract: | Intrauterine fetal growth restriction (IUGR), the main cause of premature delivery and fetal mortality, has been suggested to involve oxidative stress. We found elevated values of indices of oxidative stress in the blood serum of pregnant women with IUGR: increased levels of malondialdehyde and 4-hydroxyalkenals, decreased activity of α-1-antitrypsin and decreased total antioxidant capacity of the serum, with respect to healthy pregnancy. Twenty day treatment with 3 g of l-arginine and 75 mg of acetylsalicylic acid daily resulted in a decrease of the level of lipid peroxidation products and augmentation of α-1-antitrypsin activity. This study confirms the occurrence of oxidative stress in IUGR and demonstrates the beneficial effect of arginine/acetylsalicylic acid therapy in reducing oxidative stress in IUGR. |
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| Keywords: | Pregnancy fetal growth restriction lipid peroxidation total antioxidant capacity α_it -1-antitrypsin arginine |
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