Antioxidant effect of FeAOX-6 on free radical species produced during iron catalyzed breakdown of tert-butyl hydroperoxide |
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| Authors: | Cristina Rota Aldo Tomasi Paola Palozza Stefano Manfredini |
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| Institution: | 1. University of Modena and Reggio Emilia, Department of Biomedical Sciences, Modena, Italy;2. University of Modena and Reggio Emilia, Department of Diagnostic and Laboratory Services, Modena, Italy;3. Institute of General Pathology, Catholic University, Rome, Italy;4. Ferrara University, Department of Pharmaceutical Sciences, Ferrara, Italy |
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| Abstract: | There is a body of evidences demonstrating, in biological systems, a cooperative interaction between tocopherols and carotenoids. FeAOX-6 is a novel antioxidant that combines the chroman head of α-tocopherol and a fragment of the isoprenyl chain of lycopene. We have tested its antioxidant effect on different radical species generated in a chemical system, where peroxyl, alkoxyl and methyl radicals are generated by the ferrous ion-mediated decomposition of tert-butyl hydroperoxide. We found that FeAOX-6 has the same effectiveness of α-tocopherol in quenching peroxyl radical with no contribution by lycopene. The antioxidant activity of FeAOX-6 on alkoxyl and methyl radicals is comparable to that of the equimolar mixture of the parent compounds. Lycopene is able to quench alkoxyl radical, while it has no effect on peroxyl radical, showing a different antioxidant activity compared to other carotenoids, such as β-carotene and lutein. |
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| Keywords: | Free radicals FeAOX-6 lycopene vitamin E ESR spectroscopy |
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