1-Methyl-3-nitropyridine: An Efficient Oxidant of NADH in Non-enzymatic and Enzyme-mediated Processes |
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| Authors: | Marzena Wieczorkowska Jacek Zielonka Joanna Celińska Jan Adamus Ewa Ciesielska Andrzej Marcinek |
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| Institution: | 1. Institute of Applied Radiation Chemistry Technical University Zeromskiego 116 90-924 Lodz Poland;2. Institute of Physiology and Biochemistry Medical University Mazowiecka 6 92-215 Lodz Poland |
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| Abstract: | It is shown that NADH can be effectively oxidized by 1-methyl-3-nitropyridine in non-enzymatic and enzyme-mediated processes. Mechanistic issues of these reactions are discussed. These processes seem to contribute to the observed cytotoxicity of 1-methyl-3-nitropyridine. A key role of 1-methyl-3-nitropyridinyl radical formed in the enzyme-mediated processes is emphasized. |
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| Keywords: | Nadh Xanthine Oxidase Pyridinium Salts Enzyme Mediated Processes |
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