S-allyl cysteine prevents CCl4-induced acute liver injury in rats |
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| Authors: | Shintaro Kodai Shigekazu Takemura Yukiko Minamiyama Seikan Hai Satoshi Yamamoto Shoji Kubo |
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| Institution: | 1. Department of Hepato–Biliary–Pancreatic Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japans-kodai@med.osaka-cu.ac.jp;3. Department of Hepato–Biliary–Pancreatic Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan;4. Department of Anti-Aging Food Sciences, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan |
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| Abstract: | Aged garlic extract (AGE) possesses multiple biological activities. We evaluated the protective effect of S-allyl cysteine (SAC), one of the organosulfur compounds of AGE, against carbon tetrachloride (CCl4)-induced acute liver injury in rats. SAC was administrated intraperitoneally (50–200 mg/kg). SAC significantly suppressed the increases of plasma ALT and LDH levels. SAC also attenuated histological liver damage. CCl4 administration induced lipid peroxidation accompanied by increases in the plasma malondialdehyde and hepatic 4-hydroxy-2-nonenal levels, and SAC dose-dependently attenuated these increases. The hepatic total level of hydroxyoctadecadienoic acid (HODE), a new oxidative stress biomarker, was closely correlated with the amount of liver damage. These results suggest that SAC decreased CCl4-induced liver injury by attenuation of oxidative stress, and may be a better therapeutic tool for chronic liver disease. |
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| Keywords: | Aged garlic extract S-allyl cysteine reactive oxygen species hydroxyoctadecadienoic acid (HODE) |
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