| Biomimetic Leukocyte Adhesion： A Review of Microfluidic and Computational Approaches and Applications |
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| 作者姓名： | J. Hanzlik E. Cretekos K. A. Lamkin-Kennard |
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| 作者单位： | Department of Mechanical Engineering;Rochester Institute of Technology;Rochester; |
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| 基金项目： | supported by the National Institutes of Health HL-088685. |
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| 摘 要： | Leukocyte rolling and adhesion are complex physiological processes that have received a great deal of attention over the past decade. Significant increases in the knowledge base related to how leukocytes adhere in shear flows have occurred as a result of the development of novel experimental and computational techniques. Micro- and nano-fabrication techniques have enabled the development of novel flow devices for studying leukocyte adhesion in simple and complex geometries. Improvements in computer technology have enabled simulations of complex flow processes to be developed. As a result of these advances in knowledge related to leukocyte adhesion, numerous novel devices have been developed that mimic the leukocyte rolling and adhesion process. Examples of these devices include cell separation and enrichment devices and targeted ultrasound contrast agents. Future advances related to leukocyte rolling and adhesion processes hold great promise for advancing our knowledge of disease processes as well as development of novel therapeutic devices.
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| 关 键 词： | 仿生学 白细胞 微观流控技术 液体动力学 |
Biomimetic Leukocyte Adhesion: A Review of Microfluidic and Computational Approaches and Applications |
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| J. Hanzlik,E. Cretekos,K. A. Lamkin-Kennard.Biomimetic Leukocyte Adhesion: A Review of Microfluidic and Computational Approaches and Applications[J].Journal of Bionics Engineering,2008,5(4):317-327. |
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| Authors: | JHanzlik ECretekos KALamkin-Kennard |
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| Institution: | Department of Mechanical Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA |
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| Abstract: | Leukocyte rolling and adhesion are complex physiological processes that have received a great deal of attention over the past decade. Significant increases in the knowledge base related to how leukocytes adhere in shear flows have occurred as a result of the development of novel experimental and computational techniques. Micro- and nano-fabrication techniques have enabled the development of novel flow devices for studying leukocyte adhesion in simple and complex geometries. Improvements in computer technology have enabled simulations of complex flow processes to be developed. As a result of these advances in knowledge related to leukocyte adhesion, numerous novel devices have been developed that mimic the leukocyte rolling and adhesion process. Examples of these devices include cell separation and enrichment devices and targeted ultrasound contrast agents. Future advances related to leukocyte rolling and adhesion processes hold great promise for advancing our knowledge of disease processes as well as development of novel therapeutic devices. |
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| Keywords: | leukocyte microfluidics hydrodynamics |
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