A leucine-rich diet and exercise affect the biomechanical characteristics of the digital flexor tendon in rats after nutritional recovery |
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Authors: | Alexandre Wesley Carvalho Barbosa Gustavo Pereira Benevides Leda Maria Totti Alferes Emilianne Miguel Salomão Maria Cristina Cintra Gomes-Marcondes Laurecir Gomes |
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Institution: | 1. Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), Campinas, S?o Paulo, 13083-970, Brazil
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Abstract: | An increase in the capacity of athletic performance depends on adequate nutrition, which ensures optimal function of the musculoskeletal
system, including tendon stability. However, little is known about the status of tendons and extracellular matrix modifications
during malnutrition and nutritional recovery when leucine is used in response to exercise conditioning. The purpose of this
study was to evaluate the collagen content and biomechanical aspects of the deep digital flexor tendon (DDFT) in malnourished
rats submitted to nutritional recovery (control diet or leucine-rich diet) and aerobic physical activity. After 60 days of
undernourishment (6% protein diet), the malnourished rats were subsequently nutritionally recovered with a control diet or
leucine-rich diet and trained or not (swimming, without overload) for 5 weeks. The biomechanical analysis and quantification
of hydroxyproline were assessed in the DDFT in all experimental groups. The leucine-rich diet increased hydroxyproline content
in the tension region, independently of the training. In the compression region, hydroxyproline content was higher in the
malnourished and leucine-trained groups. Biomechanical analysis showed a lower load in the malnourished and all-trained groups.
The lowest stress was observed with control-trained animals. The nutritional-recovered groups showed higher strain values
corresponding to control group, while the lowest values were observed in malnourished and trained groups. The results suggest
that a leucine-rich diet stimulates collagen synthesis of the DDFT, especially when in combination with physical exercise,
and seems to determine the increase of resistance and the biomechanical characteristics of tendons. |
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