Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by Chlorella |
| |
Authors: | Kuramoto T Iwamoto K Izumi M Kirihata M Yoshizako F |
| |
Institution: | Research Institute for Advanced Science and Technology, Osaka Prefecture University, Japan. |
| |
Abstract: | Chlorella pyrenoidosa Chick reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 53/47. The enantiomer excesses of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters were 89 and > 99ee% respectively. C. vulgaris and C. regularis afforded predominantly the syn-isomer, contrary to C. pyrenoidosa. The differences in the activity of reducing ethyl 2-methyl 3-oxobutanoate were observed among three strains of Chlorella. Addition of 2% metal salts slightly increased the chemical yield of the hydroxy ester. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|