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Syntheses and structural characterization of rhenium-bis-hydrazinopyrimidine core complexes with thiolate and Schiff base coligands |
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| Authors: | Frank J. Femia Xiaoyuan Chen Kevin P. Maresca John W. Babich Jon Zubieta |
| Affiliation: | a Room 1-014, Department of Chemistry, Syracuse University, Syracuse, NY 13244-4100, USA b Biostream, Inc., 160 Second Street, Cambridge, MA 02142, USA |
| Abstract: | The reaction of perrhenate with 2-hydrazinopyrimidine in MeOH–HCl yields [ReCl3(η1-NNC4H3N2H)(η2-HNNC4H3N2)] (1). The analogous reaction with Na2MoO4 yields [MoCl3(η1-NNC4H3N2H)(η2-HNNHC4H3N2)] (1a). The reaction of 1 with pyrimidine-2-thiol and triethylamine produces [Re(η1-C4H3N2S)(η2-C4H3N2S)(η1-NNC4H3N2)(η2-HNNC4H3N2)] (2), while reaction of 1 with the Schiff base HSC6H4N=C(H)C6H4OH provides [Re(η3-SC6H4N=C(H)C6H4O)(η1-NNC4H3N2)(η2-HNNC4H3N2)]·0.6CH2Cl2 (3·0.6CH2Cl2). The analogous hydrazinopyridine complex of the Schiff base, [Re(η3-SC6H4N=C(H)C6H4O)(η1-NNC5H4N)(η2-HNNC5H4N)] (4), was also synthesized by reacting [ReCl3(η1-NNC5H4NH)(η2-HNNC5H4N)] with HSC6H4N=C(H)C6H4OH. The crystal structures of 1–4 have been determined. |
| Keywords: | Rhenium-hydrazinopyrimidine compounds Rhenium-Schiff base compounds Radiopharmaceuticals X-ray structures |
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