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| 慢性吗啡依赖树鼩模型的建立 | |
| 作者姓名： | Sun YM Yang JZ Sun HY Ma YY Wang JH |
| 作者单位： | 1. 中国科学院昆明动物研究所, 云南 昆明650223; 2. 中国科学院研究生院, 北京100049 |
| 基金项目： | “973”项目((2011CB707800); 中国科学院知识创新工程重要方向项目(KSCX2-EW-R-11) |
| 摘 要： | 吗啡是一种有效的镇痛药,但易使动物产生耐受性和成瘾性。在该实验中,中缅树鼩(Tupai a belangeri chinensis)连续7d,每天接受三次肌肉注射递增剂量(5、10、15、20mg/kg体重)吗啡后对吗啡产生耐受和依赖;吗啡注射完成后,腹腔注射纳洛酮(1.25mg/kg体重)催瘾,可诱导其条件性位置厌恶(conditioned place aversion,CPA)及相应吗啡戒断症状的出现。该结果提示树鼩慢性吗啡依赖模型的建立可用于研究吗啡依赖和耐受的生物学机制,以及减轻戒断症状药物的筛选。 |
| 关 键 词： | 树鼩 吗啡 慢性依赖 条件性位置厌恶 戒断症状 |
| 收稿时间： | 2011-12-19 |
| 修稿时间： | 2012-01-05 |
Establishment of tree shrew chronic morphine dependent model |
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| Sun YM,Yang JZ,Sun HY,Ma YY,Wang JH.Establishment of tree shrew chronic morphine dependent model[J].Zoological Research,2012,33(1):14-18. | |
| Authors: | Sun Yong-Mei Yang Jian-Zhen Sun Hua-Ying Ma Yuan-Ye Wang Jian-Hong |
| Institution: | 1. Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, 650223, China; 2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China |
| Abstract: | The clinical use of morphine to reduce pain is limited because of its drug tolerance, dependence and addiction. In the present study, the tree shrews (Tupaia belangeri chinensis) developed morphine tolerance and chronic morphine dependence by morphine injections with increasing doses (5, 10, 15, 20 mg/kg body weight for 7 days). Meanwhile, the naloxone (1.25 mg/kg body weight)-induced conditioned place aversion (CPA) and the withdrawal symptom were also found. The tree shrew model of chronic morphine dependence can be used to investigate the withdrawal symptoms and to select potential withdrawal symptoms reducing drugs in the future. |
| Keywords: | Tree shrew Morphine Chronic dependence Conditioned place aversion Withdrawal symptom |
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