Significant decrease in plasma midregional proadrenomedullin level in patients with end-stage renal disease after living kidney transplantation |
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| Institution: | 1. Analytical & Testing Center, Sichuan University, Chengdu 610064, China;2. Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China;3. Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China;1. Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20224, Taiwan;2. Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan;3. Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 20224, Taiwan;4. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan |
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| Abstract: | Impaired renal function has been suggested to significantly impact plasma midregional proADM (MR-proADM) level. The aim of this study was to assess whether improvement of renal function after living kidney transplantation has an impact on plasma MR-proADM-like immunoreactive substance (IS) level. Eleven patients with end-stage renal disease (ESRD) who were scheduled to undergo the first living kidney allograft transplantation were enrolled. Plasma MR-proADM-IS levels were measured before and 3, 7, 10, 14, 21, 30, 60 and 90 days after kidney transplantation. Plasma MR-proADM-IS level decreased significantly from day 3 after kidney transplantation compared to before kidney transplantation. A significant negative correlation was observed between creatinine clearance and plasma MR-proADM-IS level from before to 90 days after kidney transplantation (rs = −0.70, p < 0.0001). These results suggest that recovery of kidney function after kidney transplantation may lead to decrease in plasma MR-proADM level in patients with ESRD, and that plasma MR-proADM level may depend largely on renal function. |
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| Keywords: | Mid-regional pro-adrenomedullin MR-proADM Kidney transplantation End stage renal disease Adrenomedullin |
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