Copeptin,adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus |
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| Institution: | 1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital Beijing, China;2. National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) Beijing, China;3. Key Laboratory of Assisted Reproduction, Ministry of Education (Peking University) Beijing, China;4. Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing, China;5. Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences Beijing, China;1. Department of Neurosurgery, Elazig Education and Research Hospital, 23100, Elazig, Turkey;2. Laboratory of Medical Biochemistry, Elazig Education and Research Hospital, Elazig 23100, Turkey;3. Firat University, School of Medicine, Department of Medical Biochemistry (Firat Hormones Research Group), 23119 Elazig, Turkey;4. Firat University, School of Medicine, Department of Histology&Embryology, 23119, Elazig, Turkey;5. Cardiovascular Surgery- Anatomy, Elazig Education and Research Hospital, 23100, Elazig, Turkey;6. Firat University, Veterinary of Medicine, Department of Surgery, Elazig 23119, Turkey;1. Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding 071000, Hebei, China;2. Hebei Provincial Center for Optical Sensing Innovations, Baoding 071000, Hebei, China |
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| Abstract: | Copeptin, adropin and irisin are polypeptide hormones implicated in energy homostasis and diabetes. The purposes of this study were (1) to compare the copeptin, adropin and irisin concentrations between colostrum, transitional and mature milk and plasma in lactating women with and without GDM and (2) to compare these values with those from non-lactating women. Venous blood samples were obtained before suckling from 15 healthy lactating women aged 26–30 years, 15 lactating women with GDM aged 26–32 years, and 14 age-matched controls aged 25–31 years. Colostrum, transitional milk and mature milk samples were collected just before suckling. The concentration of copeptin was determined by EIA while the concentrations of adropin and irisin were determined by ELISA. The levels of copeptin, adropin and irisin in the colostrum were significantly higher than those in transitional and mature milk samples from healthy women; also, transitional milk had higher copeptin, adropin and irisin concentrations than mature milk. The amounts of copeptin in the colostrum and transitional milk were significantly higher than in mature milk samples from women with GDM, while the amounts of adropin and irisin were significantly lower. The relative concentrations of copeptin, adropin and irisin in the plasma samples from these groups of women were similar to those in the colostrum, transitional and mature milk samples, but the latter concentrations were higher than those in the plasma. These peptides could influence the regulation of metabolic pathways and the postnatal growth and development of different organs in the newborn. |
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| Keywords: | Copeptin Adropin Irisin Breast milk Gestational diabetes mellitus |
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