|
|||||
|
|
Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects |
|
| Authors: | G Fisher PhD N Lorenzo H Abe E Fujita W H Frey C Emory M M Di Fiore A D'Aniello |
| Institution: | (1) Department of Chemistry, Barry University, Miami Shores, Florida, USA;(2) Laboratory of Marine Biochemistry, Graduate School of Agricultural Life Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan;(3) Department of Food Science and Nutrition, Kyoritsu Women's University, Chiyoda-Ku, Tokyo, Japan;(4) Alzheimer's Treatment and Research Center, Health Partners Foundation, St. Paul, Minnesota, USA;(5) Department of Life Science, Second University of Naples, Caserta, Italy;(6) Department of Biochemistry and Molecular Biology, Stazione Zoologica  A Dohrn , Napoli, Italy |
| Abstract: | Summary Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in ADCSF. The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain. |
| Keywords: | D- and L-Amino acids Cerebrospinal fluid Ventricular CSF Alzheimer's disease |
| 本文献已被 SpringerLink 等数据库收录！ | |