| 免疫抑制剂霉酚酸的研究及产业化进展 |
| |
| 引用本文： | 黄润业,亓兰达,陈国参,尹文兵.免疫抑制剂霉酚酸的研究及产业化进展[J].微生物学报,2021,61(10):3010-3025. |
| |
| 作者姓名： | 黄润业 亓兰达 陈国参 尹文兵 |
| |
| 作者单位： | 河南省科学院生物研究所, 河南 郑州 450008;中国科学院微生物研究所真菌学国家重点实验室, 北京 100101;中国科学院大学医学院, 北京 100049 |
| |
| 基金项目： | 国家重点研发计划（2020YFA0907801）；国家自然科学基金（21807108）；河南省科学院省级特聘研究员项目（200505006） |
| |
| 摘 要： | 霉酚酸是世界上应用最广泛的免疫抑制剂之一,市场需求巨大。目前为止,主要是通过真菌发酵的方式进行霉酚酸的工业生产,而用于生产的菌株多是经过诱变的高产短密青霉菌。本文从霉酚酸的研究应用现状、化学合成以及生物合成途径、遗传调控、发酵生产以及市场分析等方面对霉酚酸的研究及产业化进展进行了系统综述。为该药物的新颖衍生物开发、提高产率以及应用先进生物技术智能化创制提供重要参考和依据。
|
| 关 键 词： | 霉酚酸 生物合成 调控途径 发酵 |
| 收稿时间： | 2020/12/23 0:00:00 |
| 修稿时间： | 2021/2/5 0:00:00 |
Research and industrialization progress of immunosuppressant mycophenolic acid |
| |
| Runye Huang,Landa Qi,Guocan Chen,Wenbing Yin.Research and industrialization progress of immunosuppressant mycophenolic acid[J].Acta Microbiologica Sinica,2021,61(10):3010-3025. |
| |
| Authors: | Runye Huang Landa Qi Guocan Chen Wenbing Yin |
| |
| Institution: | Henan Academy of Science Institute of Biology, Zhengzhou 450008, Henan Province, China;State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China |
| |
| Abstract: | Mycophenolic acid is one of the most widely used immunosuppressant in the world, and the market demand is huge. So far, the industrial production of mycophenolic acid is mainly through fungal fermentation, and the strains used for production are mostly mutagenized high-yielding Penicillium brevicompactum. This article systematically reviews the research and industrialization progress of mycophenolic acid. Five aspects including current research and application of mycophenolic acid, chemical synthesis and biosynthetic pathways, genetic regulation, fermentation production and market analysis are described. This review will provide valuable information for the development of novel derivatives of the drug, the improvement of yield, and the intelligent creation of advanced biotechnology in the future. |
| |
| Keywords: | mycophenolic acid biosynthesis regulatory pathway fermentation |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《微生物学报》浏览原始摘要信息 |
| 点击此处可从《微生物学报》下载免费的PDF全文 |
|
