The molecular evolution of ZFY-related genes in birds and mammals |
| |
| Authors: | J Lanfear P W H Holland |
| |
| Institution: | (1) Mölecular Zoology Laboratory, Department of Zoology, University of Oxford, South Parks Road, OX1 3PS Oxford, UK;(2) Present address: Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, G61 1BD Glasgow, UK |
| |
| Abstract: | Summary We report the isolation and nucleotide sequence determination of clones derived from five ZFY-related zinc-finger genes from birds and mammals. These sequences are analyzed with reference to the previously published human genes, ZFX and ZFY, and mouse genes, Zfx, Zfa, Zfy-1, and Zfy-2. The analysis indicates that ZFY-related genes are highly conserved in birds and mammals, and that the rate of nucleotide substitution in the Y-linked genes is not as high as predicted. However, the mouse Zfy-1 and Zfy-2 genes are markedly divergent members of the ZFY gene family; we suggest this relates to X-inactivation of the mouse gene Zfx. |
| |
| Keywords: | DNA evolution ZFY Divergence Polymerase chain reaction Sex determination Zinc fingers |
| 本文献已被 SpringerLink 等数据库收录！ |
|
