Codon usage in the vertebrate hemoglobins and its implications |
| |
Authors: | Smith TF; Ralph WW; Goodman M; Czelusniak J |
| |
Institution: | Bio-Statistics, Harvard School of Public Health, Northern Michigan University, Marquette 49855. |
| |
Abstract: | A study of codon usage in vertebrate hemoglobins revealed an evolutionary
trend toward elevated numbers of CpG codon boundary pairs in mammalian
hemoglobin alpha genes. Selection for CpG codon boundaries countering the
generally observed CpG suppression is strongly suggested by these data.
These observations parallel recently published experimental results that
indicate that constitutive expression of the human alpha-globin gene
appears to be determined by regulatory information encoded within the
structural gene. The possibility is raised that, in the absence of
selection, CpG decay can be used to date the evolutionary origin of a
mammalian alpha pseudogene from its active alpha gene.
|
| |
Keywords: | |
本文献已被 Oxford 等数据库收录! |
|