Histidine modulates the clastogenic effect of oxidative stress |
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| Authors: | P Tachon P U Giacomoni |
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| Affiliation: | Laboratoires de Recherche Fondamentale de L'Oréal, Aulnay sous Bois, France. |
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| Abstract: | The kinetics of the formation of single-strand breaks induced by H2O2 in DNA is more rapid in Eagle's Modified Minimal Essential Medium (MEM) than in phosphate-buffered saline (PBS). Among the components of MEM, we found that histidine increases the rate of degradation of DNA by H2O2 in PBS dose-dependently. In hamster lung fibroblasts histidine increases the cytotoxicity of H2O2, as well as the number of sister-chromatid exchanges and the frequency of micronuclei induced by hydrogen peroxide. |
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