Evidence for corticotropin releasing factor (CRF) synthesis in the preoptic nucleus of Xenopus laevis tadpoles |
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| Authors: | Dr C D Notenboom Dr M Terlou Marianne L Maten |
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| Institution: | (1) Zoological Laboratory, State University, Utrecht, The Netherlands;(2) Zoological Laboratory, Transitorium 3, Padualaan 8, Utrecht, The Netherlands;(3) Present address: Stichting Opleiding Leraren, Rooseveltlaan 560b, Utrecht, The Netherlands |
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| Abstract: | Summary For the study of the hypothalamo-hypophysial system of Xenopus laevis tadpoles, hypothalamic lesions were made by means of the electrocoagulation technique. Lesioning of the ventral region of the preoptic nucleus resulted in a decrease of the number of ACTH cells in the pars distalis of the pituitary gland and in a diminution of the PAS-positive reaction of these cells. In addition, regeneration of the neurosecretory cells of the ventral region of the preoptic nucleus observed 6 weeks after lesioning was accompanied by the reappearance of normal PAS-positive ACTH cells in the pars distalis. It is suggested that the neurosecretory cells of the ventral region of the preoptic nucleus of Xenopus laevis tadpoles are related to the ACTH synthesizing cells, probably by producing CRF.Dedicated to Prof. Dr. med. W. Bargmann on the occasion of his 70th birthdayThe authors thank Prof. Dr. J.C. van de Kamer for his interest, Prof. Dr. P.G.W.J. van Oordt for his many helpful comments, and Messrs. H. van Kooten, E. van der Vlist, J.J. van der Vlis and M.C.A. van Pinxteren for preparing the illustrations |
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| Keywords: | Hypothalamo-hypophysial system Preoptic nucleus Corticotropin Releasing Factor Xenopus laevis tadpoles Lesions |
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