TRPC6在中枢神经系统的作用

TRPC6（Thetransientreceptorpotentialcanonical6）为瞬时受体电位（TRP）超家族的成员之一，编码钙可通透的非选择性阳离子通道。其具有六次跨膜结构。TRPC6同型或异型四聚体通道由TRPC6蛋白相互结合形成或与同在一个亚家族的TRPC3，TRPC7形成。TRPC6通道可被G蛋白耦联受体（GPCR）和受体酪氨酸激酶（receptortyrosinekinasesRTK）通过激活磷脂酶C（PLC）激活。其还可直接被第二信使DAG（diacylglycer01）激活。已有研究证实该通道通过激活上述信号传导通路参与了多种生理过程。TRPC6基因编码的蛋白在人体多个部位均有表达。TRPC6在中枢神经系统广泛表达。其在不同部位的表达量不同，并与TRPC家族的其他成员一起参与了多种生理过程。TRPC6引起的细胞阳离子浓度的变化可能参与了多种神经系统疾病的发生发展过程。因此。研究TRPC6在中枢神经系统中的作用对疾病发病机制的了解及治疗变得更有意义。本文就TRPC6在中枢神经系统中的作用进行综述，并主要介绍其在树突发育，神经元保护及细胞生长方面的作用。

The Effects of TRPC6 in CNS

TRPC6, a member of the TRP family, is a Ca2＋-permeable non-selective cation channel composed of tetrameric assemblies of 6 transmembrane spanning subunits. Experimental approaches employed led to the conclusion that TRPC6 assembles into homo- and heterotetramers within the confines of the TRPC3/6/7 subfamily .The channel can be activated by a phospholipase C dependent mechanism through activation of both G protein-coupled receptors （GPCR） and receptor tyrosine kinases. Also it can be directly activated by the second messenger diacylglycerol （DAG）.These have been implicated in a variety of biological fimctions .TRPC6 abroadly expressed in human tissues and cells. Minimal variation in the expression was observed between the different tissues and cell in Central nervous system （CNS）. And it takes part in an array of biological functions together with other member of TRPC subfamily. TRPC6 is highly expressed in central nervous system, which causes changes of the concentration of some cations. In addition, a striking number of central nervous system diseases have already been assigned to TRPC6. Therefore, the understanding of disease pathogenesis and treatment of of TRPC6 role in the central nervous system of the more meaningful.The aim of the present study was to observe the effects of TRPC6 in CNS, especially in neurite outgrowth, cell proliferation, neuronal survival.