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Proteomic Profiling of Paired Interstitial Fluids Reveals Dysregulated Pathways and Salivary NID1 as a Biomarker of Oral Cavity Squamous Cell Carcinoma,
Institution:3. Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan;4. Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan;5. Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan;6. Department of Pathology, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan;12. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan;8. Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan;9. Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan;10. Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
Abstract:
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  • Highlights
    • ?Proteome profiling of tissue interstitial fluids (TIFs) of oral cancer.
    • ?Pathway of aminoacyl tRNA biosynthesis enriched in proteome of TIFs.
    • ?Verification of nidogen-1 as a salivary biomarker of oral cancer.
    • ?High correlation between elevated tissue level of nidogen-1 and poor survival.
    Keywords:Head and neck cancer  Biofluids  Biomarker: Prognostic  Biomarker: Diagnostic  Label-free quantification  interstitial fluids  oral cancer
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