Substantial Influence of ERAP2 on the HLA-B*40:02 Peptidome: Implications for HLA-B*27-Negative Ankylosing Spondylitis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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*Substantial Influence of ERAP2 on the HLA-B40:02 Peptidome: Implications for HLA-B27-Negative Ankylosing Spondylitis*

Institution:	3. Centro de Biología Molecular Severo Ochoa (CSIC-UAM), 28049 Madrid, Spain;4. Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda Madrid, Spain;5. Faculty of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel

Abstract:	Download : Download high-res image (115KB) Download : Download full-size image Highlights •HLA-B40:02 and ERAP2 are risk factors for ankylosing spondylitis. •The effects of ERAP2 on the B40:02 peptidome are defined. •ERAP2 has a major influence mainly due to alterations of N-terminal residues. •These effects provide a basis for the association of ERAP2 with disease.

Keywords:	Peptidomics Immunology Inflammation Label-Free Quantification Enzyme Mechanisms Ankylosing Spondylitis ERAP2 HLA-B*40
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