首页 | 本学科首页   官方微博 | 高级检索  
     


Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid
Affiliation:3. From the 3Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain;;4. 4Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain;;5. 5Biomedical Research Institute Sant Pau (IIB Sant Pau), 08025Barcelona, Spain;;6. 6Proteomics Unit, Center for Genomics Regulation, Barcelona Institute of Science and Technology, 08003 Barcelona;;12. 12Alzheimer''s Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clínic-Institut d''Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 08015 Barcelona, Spain;;8. 8Department of Neurology, Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, 20009 San Sebastian, Spain;;10. 10Centre for Discovery Brain Sciences and UK Dementia Research Institute, University of Edinburgh EH8 9JZ, UK;;123. 123Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Spain
Abstract:
><ol class=
  • Download : Download high-res image (176KB)
  • Download : Download full-size image
  • Highlights
    • •Proteomic analysis of cerebrospinal fluid and identification of synaptic component.
    • •Use of super resolution microscopy to verify synapse-specificity in human tissue.
    • •Selective reaction monitoring MS (SRM) of synaptic panel in 3 cohorts of Alzheimer's disease cerebrospinal fluid.
    • •Synaptic protein changes precede tau in preclinical Alzheimer's disease.
    Keywords:Selected reaction monitoring  Clinical proteomics  Alzheimer's disease  Biomarker: Prognostic  Cerebrospinal fluid
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号