Associations of the Fecal Microbial Proteome Composition and Proneness to Diet-induced Obesity
Institution:
3. 3Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA;4. 4Department of Pharmacology, University of California, San Diego, CA;5. 5Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA;6. 6Department of Pediatrics, and Department of Computer Science and Engineering, University of California, San Diego, CA;12. 12Neuroscience Institute, Georgia State University, Atlanta, GA;8. 8School of Psychology, Georgia Institute of Technology, Atlanta, GA 30332
Abstract:
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Highlights
?Feeding mice a western-style obesogenic diet resulted in dramatic changes in fecal microbial proteome.
?Basal fecal microbial proteome, but not microbiome, composition was associated with extent of diet-induced obesity.
?A major feature of fecal microbial proteome of high-responder mice was enriched motility-related proteins.
